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KMID : 1149220050130010071
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Korean Journal of Oriental Medical Prescription
2005 Volume.13 No. 1 p.71 ~ p.83
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The Effects of Chelidonii Herba Extract on Apoptosis in Human Stomach Adenocarcinoma Cell Line
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Kim Sang-Chan
Lee Sang-Tae
Kim Dae-Jun
Byun Joon-Seok
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Abstract
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Chelidonii Herba (Baekgulchae in Korean: CHE), a commonly used herb in Korea, Japan and China, is widely used in the treatment of stomach cancer, jaundice, gastric ulcer, edema and pain of stomach. In the present study, we demonstrated that CHE induces apoptosis in AGS cells, human stomach adenocarcinoma cell line. One of the most important recent advances in cancer research is the recognition that apoptosis plays a major role in both tumor formation and treatment response, In this study, CHE caused a decrease of viability in AGC cells. When AGS cells were treated with CHE, cells showed dose-dependent manner apoptotic cell death. Increased apoptotic cell death, exposured to CHE, resulted from induction of Bad translocation to mitochondria, cytochrome-c release from mitochondria to cytosol, activation of caspase-3, 8, 9, and PARP cleavage. These results suggest that CHE may be potential therapeutic approach in the clinical management of stomach adenocarcinoma.
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KEYWORD
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AGS cells, apoptosis, Chelidonii Herba, stomach adenocarcinoma
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